Parathyroid Disease

What is parathyroid disease?

Parathyroid disease affects the parathyroids, four pea-sized glands located in the neck near the thyroid. The glands produce parathyroid hormone (PTH). PTH helps maintain the correct balance of calcium in the body. Normally, the glands release just enough PTH to keep calcium levels normal. Disease upsets this delicate balance.

There are three types of parathyroid disease: hyperparathyroidism, parathyroid cancer and hypoparathyroidism.

Hyperparathyroidism

Hyperparathyroidism (HPT) is the most common type of parathyroid disease. In HPT, one or more glands are overactive. As a result, the glands make too much PTH. This may result in too much calcium in the blood—a condition called hypercalcemia. Usually, a benign tumor on the gland causes HPT.

Hypercalcemia can cause serious problems, including:

• osteoporosis
• kidney stones
• heart disease
• high blood pressure

Most people with primary HPT have no symptoms. Some people experience mild symptoms, such as:

• muscle weakness
• fatigue
• increased need for sleep
• depression
• aches and pains in the joints and bones

Symptoms for people with more severe disease may include:

• loss of appetite
• nausea
• vomiting
• constipation
• confusion or impaired thinking and memory
• increased thirst and urination

In rare cases, two or more of the glands are overactive.

HPT is most often diagnosed in people between the ages of 50 and 60. Women are affected about three times as often as men. Some people have hypercalcemia due to a rare genetic disorder called familial hypocalciuric hypercalcemia. This condition is typically benign and does not require treatment.

In some cases, a problem such as kidney failure causes the parathyroid glands to become overactive. This is called secondary HPT.

Parathyroid Cancer

Parathyroid cancer can cause HPT. This very rare disease usually strikes people in their 50s. It often returns, or recurs, at the original site after treatment. Recurrence can be slowed by controlling the level of calcium in the blood.

Early detection is key to survival. Hypercalcemia and its associated complications often pose a greater threat to your health than the cancer itself.

Hypoparathyroidism

Hypoparathyroidism means the body does not make enough PTH. As a result, the level of calcium in the blood is too low. The condition is usually caused by neck surgery or damage to the parathyroids. It can also happen from autoimmune attacks on the glands.

Hypoparathyroidism increases the risk of:

• Addison's disease, a disorder that occurs when the adrenal glands don't make enough hormones. This risk is associated only with autoimmune-related hypoparathyroidism.
• Cataracts.
• Parkinson's disease, a progressive disorder that affects the brain and causes abnormal movements and other symptoms. See the Movement Disorders page for more information.
• Pernicious anemia, a condition in which the body cannot make enough red blood cells due to a lack of vitamin B-12. People with this disorder are unable to absorb enough B-12 from food. This risk is associated only with autoimmune-related hypoparathyroidism.

How is parathyroid disease diagnosed and evaluated?

Your doctor may diagnose parathyroid disease by testing the levels of calcium and PTH in your blood.

After diagnosis, the following tests may be done to assess complications:

Bone densitometry (DEXA, DXA):  Bone densitometry, also called DEXA or DXA, uses a very small dose of ionizing radiation to produce pictures of the inside of the body (usually the lower spine and hips) to measure bone loss. DXA is simple, quick and noninvasive.

Ultrasound: Ultrasound imaging uses sound waves to produce pictures of the inside of the body. Ultrasound is safe, noninvasive, and does not use radiation.

Computed tomography (CT) - body:  CT scans use a combination of x rays and computer technology to create three-dimensional (3-D) images. A CT scan may include the injection of contrast material. CT scans require the person to lie on a table that slides into a tunnel-shaped device where the x rays are taken. The procedure is often performed in an outpatient center, and the images are interpreted by a radiologist; anesthesia is not needed.

Magnetic resonance imaging - body: Body MRI uses a powerful magnetic field, radio waves and a computer to produce detailed pictures of the inside of your body.

25-hydroxy-vitamin D blood test: people with primary HPT commonly lack vitamin D. This test helps your doctor monitor vitamin D levels in your blood and determine if you need supplements.

How is parathyroid disease treated?

Treatment options include surgery, medication, dietary supplements and monitoring.

Surgery

Surgical removal of overactive parathyroid glands is highly effective in most patients. Surgery can benefit nearly everyone with primary HPT who exhibit symptoms. Those without symptoms but who meet guidelines for surgery also may benefit. Surgical removal of diseased parathyroids can lead to higher bone density, fewer fractures and a reduced chance of kidney stone formation.

Prior to surgery, doctors may use one or more of the following tests to locate the diseased gland(s):

• Four-dimensional computed tomography (4DCT): Parathyroid 4DCT provides a more detailed view than conventional CT. This is made possible by administering contrast material at a specific rate and time. 4DCT is particularly useful when other imaging studies fail to show the abnormal gland.
• Ultrasound: This test may be used to find benign tumors on one or more of the glands.

Surgery is then performed one of two ways:

• Minimally invasive parathyroidectomy. The surgeon removes the overactive gland through a small incision in the neck. Local or general anesthesia is used. This approach involves less pain for the patient. It also reduces recovery time compared with more invasive surgery.
• Standard neck exploration. Neck exploration is more invasive. It may be used if the surgeon plans to inspect more than one gland. A larger incision is made to access and examine all four glands and remove the overactive ones. This surgery typically requires a hospital stay of up to two days. General anesthesia is required.

The surgeon will remove tissue and send it to a pathologist for analysis. This will tell your doctor if the abnormal tissue was benign or cancerous.

Potential complications from surgery are rare. Some patients suffer damage to the nerves controlling the vocal cords. This can affect speech. Others may face chronically low calcium levels and require lifelong treatment with calcium and vitamin D. The rate of complications is slightly higher for surgeries on multiple tumors.

People with primary HPT due to familial hypocalciuric hypercalcemia should not have surgery.

Monitoring

Some people with mild primary HPT may not need surgery and can be safely monitored instead. Monitoring may be prescribed for those who have:

• no symptoms;
• only slightly elevated blood calcium levels, and;
• normal kidney function and bone density.

Monitoring typically includes:

• physical exams from time to time
• blood tests for calcium levels and kidney function
• bone density measurements

Medications

Medications called calcimimetics can decrease the amount of PTH produced by the parathyroid glands. A drug called Cinacalcet is approved for the treatment of secondary HPT caused by dialysis and primary HPT caused by parathyroid cancer. Cinacalcet has also been approved to manage hypercalcemia associated with primary HPT.

Dietary Supplements

People with low calcium levels due to the surgical removal of parathyroid tissue will need to take calcium supplements for life. People who have life-threatening attacks of low calcium levels or prolonged muscle contractions are given calcium intravenously.

Some people with primary HPT may be prescribed vitamin D supplements.

Too much vitamin D and calcium can cause hypercalcemia or high urine calcium. This may also sometimes interfere with kidney function, or even cause kidney failure.